Pub. Date : 2014 Nov 3
PMID : 25240193
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |
| 2 | While TR4 overexpression increased PC activity, oxaloacetate (OAA) and glycerol levels with enhanced incorporation of (14)C from (14)C-pyruvate into fatty acids in 3T3-L1 adipocytes, PC knockdown by short interfering RNA (siRNA) or inhibition of PC activity by phenylacetic acid (PAA) abolished TR4-enhanced fatty acid synthesis. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |
| 3 | While TR4 overexpression increased PC activity, oxaloacetate (OAA) and glycerol levels with enhanced incorporation of (14)C from (14)C-pyruvate into fatty acids in 3T3-L1 adipocytes, PC knockdown by short interfering RNA (siRNA) or inhibition of PC activity by phenylacetic acid (PAA) abolished TR4-enhanced fatty acid synthesis. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |
| 4 | Moreover, TR4 microRNA reduced PC expression with decreased fatty acid synthesis in 3T3-L1 adipocytes, suggesting that TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |
| 5 | Moreover, TR4 microRNA reduced PC expression with decreased fatty acid synthesis in 3T3-L1 adipocytes, suggesting that TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |
| 6 | Moreover, TR4 microRNA reduced PC expression with decreased fatty acid synthesis in 3T3-L1 adipocytes, suggesting that TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |
| 7 | Moreover, TR4 microRNA reduced PC expression with decreased fatty acid synthesis in 3T3-L1 adipocytes, suggesting that TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene. | Fatty Acids | nuclear receptor subfamily 2, group C, member 2 | Mus musculus |