Pub. Date : 2015 Jan
PMID : 25229889
8 Functional Relationships(s)Download |
||||||
Sentence | Compound Name | Protein Name | Organism |
|||
| 1 | Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro. | Curcumin | hexokinase 2 | Homo sapiens | ||
| 2 | On the one hand, curcumin downregulated the expression and activity of hexokinase II (HKII) in HCT116 and HT29 cells in a concentration-dependent manner, but had little effect on the other key glycolytic enzymes (PFK, PGM, and LDH). | Curcumin | hexokinase 2 | Homo sapiens | ||
| 3 | On the one hand, curcumin downregulated the expression and activity of hexokinase II (HKII) in HCT116 and HT29 cells in a concentration-dependent manner, but had little effect on the other key glycolytic enzymes (PFK, PGM, and LDH). | Curcumin | hexokinase 2 | Homo sapiens | ||
| 4 | On the other, curcumin induced dissociation of HKII from the mitochondria, resulting in mitochondrial-mediated apoptosis. | Curcumin | hexokinase 2 | Homo sapiens | ||
| 5 | Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA. | Curcumin | hexokinase 2 | Homo sapiens | ||
| 6 | Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA. | Curcumin | hexokinase 2 | Homo sapiens | ||
| 7 | Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA. | Curcumin | hexokinase 2 | Homo sapiens | ||
| 8 | These results have important implications for the metabolism reprogramming effect and the susceptibility to curcumin-induced mitochondrial cytotoxicity through the regulation of HKII, and provide a molecular basis for the development of naturally compounds as novel anticancer agents for colorectal carcinoma. | Curcumin | hexokinase 2 | Homo sapiens | ||