Pub. Date : 2014
PMID : 25229504
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cross-talk between cAMP and MAPK pathways in HSD11B2 induction by hCG in placental trophoblasts. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 2 | Human chorionic gonadotropin (hCG) plays an important role in maintaining placental HSD11B2 expression via activation of the cAMP pathway. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 3 | In this study, we investigated the relationship between the activation of the cAMP pathway by hCG and subsequent phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2) or p38 mitogen-activated protein kinase (MAPK) pathways in the regulation of placental HSD11B2 expression in human placental syncytiotrophoblasts. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 4 | These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 5 | These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 6 | These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |