Pub. Date : 2014 Sep
PMID : 25229003
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-kappaB Pathways in Nasal Polyp-Derived Fibroblasts. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | The purposes of this study were to determine whether PGE2 has any effect on the increase in the levels of IL-6 and IL-8 in nasal polyp-derived fibroblasts (NPDFs) and subsequently investigate the possible mechanism of this effect. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 7 | RESULTS: PGE2 significantly increased the mRNA and protein expression levels of IL-6 and IL-8 in NPDFs. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 8 | The Akt and NF-kappaB inhibitors significantly blocked PGE2-induced expression of IL-6 and IL-8. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 9 | These results suggest that signaling pathway for IL-6 and IL-8 expression induced by PGE2 might be a useful therapeutic target for the treatment of nasal polyposis. | Dinoprostone | C-X-C motif chemokine ligand 8 | Homo sapiens |