Pub. Date : 2014 Sep 30
PMID : 25225364
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report here that IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | These findings suggest that specialization of human neocortex for high glutamate neurotransmitter flux creates a metabolic niche conducive to growth of IDH1 mutant tumors. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |