Title : Melatonin as a proteasome inhibitor. Is there any clinical evidence?

Pub. Date : 2014 Oct 12

PMID : 25219883






1 Functional Relationships(s)
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1 Proteasome inhibitors and melatonin are both intimately involved in the regulation of major signal transduction proteins including p53, cyclin p27, transcription factor NF-kappaB, apoptotic factors Bax and Bim, caspase 3, caspase 9, anti-apoptotic factor Bcl-2, TRAIL, NRF2 and transcription factor beta-catenin. Melatonin tumor protein p53 Homo sapiens