Title : Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages.

Pub. Date : 2014 Oct 8

PMID : 25213465






2 Functional Relationships(s)
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1 Ursolic acid suppressed LPS-stimulated interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, and inducible NO synthetase (iNOS) expression as well as PGE2 and NO levels. ursolic acid nitric oxide synthase 2, inducible Mus musculus
2 Ursolic acid also suppressed TNBS-induced COX-2 and iNOS expression as well as NF-kappaB activation in colon tissues. ursolic acid nitric oxide synthase 2, inducible Mus musculus