Title : ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.

Pub. Date : 2014 Dec

PMID : 25213441






1 Functional Relationships(s)
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1 A new study shows that ATP binding to Rad50 promotes DSB recognition, tethering, and ATM activation, while ATP hydrolysis opens the nuclease active sites to promote processing of DSBs. dsbs RAD50 double strand break repair protein Homo sapiens