Pub. Date : 2015 Nov
PMID : 25213146
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation. | hirsutenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In this study, we show that hirsutenone, a bioactive compound in Alnus japonica, exhibits anti-cancer effects against prostate cancer through a direct physical inhibition of Akt1/2. | hirsutenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Furthermore, treatment of hirsutenone attenuated phosphorylation of mammalian target of rapamycin (mTOR), a downstream substrate of Akt, without affecting Akt phosphorylation. | hirsutenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Kinase and pull-down assay results clearly show that hirsutenone inhibits Akt1 and 2 by direct binding in an adenosine triphosphate (ATP)-noncompetitive manner in vitro and ex vivo. | hirsutenone | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Our results show that hirsutenone suppresses human prostate cancer by targeting Akt1 and 2 as a key component to explain for anti-cancer activity of Alnus species. | hirsutenone | AKT serine/threonine kinase 1 | Homo sapiens |