Title : Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase.

Pub. Date : 2014 Sep 10

PMID : 25209287






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mechanistically, the actions of submicromolar levels of SP were NK1R-dependent, whereas subpicomolar SP-elicited actions required microglial NADPH oxidase (NOX2), the key superoxide-producing enzyme, but not NK1R. Superoxides cytochrome b-245, beta polypeptide Mus musculus