Pub. Date : 2014 Sep 26
PMID : 25201730
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our data suggest that mitochondrial protein cyclophilin D (Cyp-D)-dependent mitochondrial permeability transition pore (mPTP) opening mediates cinobufotalin-induced non-apoptotic death of lung cancer cells. | cinobufotalin | peptidylprolyl isomerase F (cyclophilin F) | Mus musculus |
| 2 | Our data suggest that mitochondrial protein cyclophilin D (Cyp-D)-dependent mitochondrial permeability transition pore (mPTP) opening mediates cinobufotalin-induced non-apoptotic death of lung cancer cells. | cinobufotalin | peptidylprolyl isomerase F (cyclophilin F) | Mus musculus |
| 3 | The Cyp-D inhibitor cyclosporine A (CsA), the mPTP blocker sanglifehrin A (SfA), and Cyp-D shRNA-silencing significantly inhibited cinobufotalin-induced mitochondrial membrane potential (MMP) reduction and A549 cell death (but not apoptosis). | cinobufotalin | peptidylprolyl isomerase F (cyclophilin F) | Mus musculus |
| 4 | The Cyp-D inhibitor cyclosporine A (CsA), the mPTP blocker sanglifehrin A (SfA), and Cyp-D shRNA-silencing significantly inhibited cinobufotalin-induced mitochondrial membrane potential (MMP) reduction and A549 cell death (but not apoptosis). | cinobufotalin | peptidylprolyl isomerase F (cyclophilin F) | Mus musculus |
| 5 | Thus, cinobufotalin mainly induces Cyp-D-dependent non-apoptotic death in cultured lung cancer cells. | cinobufotalin | peptidylprolyl isomerase F (cyclophilin F) | Mus musculus |