Title : Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration.

Pub. Date : 2014

PMID : 25197371






2 Functional Relationships(s)
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1 TUNEL assay was used to assess the ketamine-induced neurodegeneration of hippocampal CA1 neurons, quantitative real-time PCR (qRT-PCR) to assess the expression of miR-137 and Morris water maze test (MWM) to assess the damaged memory function. Ketamine carbonic anhydrase 1 Rattus norvegicus
2 RESULTS: Excessive ketamine treatment resulted in severe apoptosis in hippocampal CA1 neurons, downregulation of miR-137 in hippocampus and significant long-term memory dysfunction. Ketamine carbonic anhydrase 1 Rattus norvegicus