Title : The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells.

Pub. Date : 2015 Jan 5

PMID : 25179820






3 Functional Relationships(s)
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Protein Name
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1 Metformin inhibited mammalian target of rapamycin complex 1 (mTORC1) activity by phosphorylating the mTORC1 component raptor. Metformin CREB regulated transcription coactivator 1 Mus musculus
2 Metformin inhibited mammalian target of rapamycin complex 1 (mTORC1) activity by phosphorylating the mTORC1 component raptor. Metformin CREB regulated transcription coactivator 1 Mus musculus
3 This study revealed the anti-angiogenic activity of metformin in ELT-3 cells by suppressing the expression of VEGF via the mTORC1/HIF-1alpha pathway. Metformin CREB regulated transcription coactivator 1 Mus musculus