Title : Elevation in 5-FU-induced apoptosis in head and neck cancer stem cells by a combination of CDHP and GSK3β inhibitors.

Pub. Date : 2015 Mar

PMID : 25169655






3 Functional Relationships(s)
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1 RESULTS: CD44(high) /ESA(low) cells exhibited marked resistance to 5-FU-induced apoptosis and had high expression of dihydropyrimidine dehydrogenase (DPD). Fluorouracil CD44 molecule (Indian blood group) Homo sapiens
2 The DPD inhibitor, 5-chloro-2, 4-dihydroxypyridine (CDHP) significantly enhanced 5-FU-induced apoptosis of CD44(high)/ESA(low) cells. Fluorouracil CD44 molecule (Indian blood group) Homo sapiens
3 Combination of both CDHP and GSK3beta inhibitors markedly enhanced 5-FU-induced apoptosis of CD44(high) /ESA(low) cells. Fluorouracil CD44 molecule (Indian blood group) Homo sapiens