Title : Rotenone remarkably attenuates oxidative stress, inflammation, and fibrosis in chronic obstructive uropathy.

Pub. Date : 2014

PMID : 25140114






1 Functional Relationships(s)
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1 In line with the improvement of kidney morphology, rotenone remarkably blunted fibrotic response as shown by downregulation of fibronectin (FN), plasminogen activator inhibitor-1 (PAI-1), collagen I, collagen III, and alpha-SMA, paralleled with a substantial decrease of TGF-beta 1. Rotenone actin alpha 2, smooth muscle, aorta Mus musculus