Title : Strategy to enhance the anticancer efficacy of X-ray radiotherapy in melanoma cells by platinum complexes, the role of ROS-mediated signaling pathways.

Pub. Date : 2014 Nov 1

PMID : 25135223






1 Functional Relationships(s)
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1 Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction. ros AKT serine/threonine kinase 1 Homo sapiens