Pub. Date : 2014 Dec
PMID : 25131138
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-Catenin and c-Myc protein expression following cisplatin treatment were determined using western blotting and immunofluorescence. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Endogenous beta-catenin and c-Myc expression in A549/DDP cells were higher than that in A549 cells, and were upregulated in A549/DDP cells (p < 0.05) and downregulated in A549 cells after 48 h cisplatin treatment (p < 0.05). | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | beta-catenin localization transferred from membrane/cytoplasmic/nuclear to cytoplasmic/nuclear, and c-Myc localization transferred from cytoplasmic/nuclear to nuclear in both cell lines following cisplatin treatment. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | C-myc, the downstream target gene of beta-catenin, plays an important role in regulating cisplatin resistance in A549/DDP cells. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | C-Myc siRNA improved the sensitivity of A549/DDP cells to cisplatin. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |