Title : The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons.

Pub. Date : 2015 Mar

PMID : 25125027






2 Functional Relationships(s)
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1 The rate-limiting step of GABA synthesis is catalyzed by two glutamic acid decarboxylase isoforms GAD65 and GAD67 coexpressed in the GABAergic neurons of the CNS. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
2 Our results also suggest that GAD65 and GAD67/EGAD characterized by distinct subcellular localization and kinetics have disparate functions during olfactory system development mediating proliferative and migratory responses putatively through specific subcellular GABA pools. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus