Title : The IRP/IRE system in vivo: insights from mouse models.

Pub. Date : 2014

PMID : 25120486






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism. Iron aconitase 1 Mus musculus
2 Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism. Iron aconitase 1 Mus musculus
3 Thus, IRP1 emerged as a key regulator of erythropoiesis and iron absorption by controlling hypoxia inducible factor 2alpha (HIF2alpha) mRNA translation, while IRP2 appears to dominate the control of iron uptake and heme biosynthesis in erythroid progenitor cells by regulating the expression of transferrin receptor 1 (TfR1) and 5-aminolevulinic acid synthase 2 (ALAS2) mRNAs, respectively. Iron aconitase 1 Mus musculus