Title : Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.

Pub. Date : 2014 Aug 6

PMID : 25100739






1 Functional Relationships(s)
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1 To devise a different strategy, we engineered and optimized the apyrase activity of human nucleoside triphosphate diphosphohydrolase-3 (CD39L3) to enhance scavenging of extracellular adenosine diphosphate, a predominant ligand of P2Y12 receptors. Adenosine Diphosphate ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens