Title : Molecular mechanisms contributing to the protective effect of levosimendan in liver ischemia-reperfusion injury.

Pub. Date : 2014 Oct 15

PMID : 25094034






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1 The hepatoprotective effect of levosimendan was partially attenuated by pretreatment by either nonselective COX inhibitor, NOS inhibitor, or K-ATP channel blocker; indicating that the hepatoprotective effect of levosimendan was attributed, at least in part to activation of COX-1, modulation of NO, and opening of K-ATP channel. Simendan cytochrome c oxidase I, mitochondrial Rattus norvegicus