Title : Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy.

Pub. Date : 2015 Jan

PMID : 25092802






1 Functional Relationships(s)
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1 Inhibition of astrocyte proliferation by ammonia was mediated by a l-methionine sulfoximine-, oxidative stress-, and p38(MAPK) -dependent activation of p53 associated with enhanced transcription of cell cycle inhibitory genes GADD45alpha and p21. L-Methionine sulfoximine tumor protein p53 Homo sapiens