Title : Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.

Pub. Date : 2014 Aug 22

PMID : 25086357






3 Functional Relationships(s)
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1 In addition, we observed reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine reversed the down-regulation of CBS and H2S generation caused by rotenone in microglia. Reactive Oxygen Species cystathionine beta-synthase Mus musculus
2 In addition, we observed reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine reversed the down-regulation of CBS and H2S generation caused by rotenone in microglia. Reactive Oxygen Species cystathionine beta-synthase Mus musculus
3 Taken together, these results reveal that probably via triggering ROS formation, rotenone suppressed the CBS-H2S pathway and thus promoted microglia polarization toward M1 pro-inflammatory phenotype. Reactive Oxygen Species cystathionine beta-synthase Mus musculus