Pub. Date : 2014 Sep 12
PMID : 25086031
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Single site mutants at Ser residues embedded in potential PKC consensus sites (Ser(18), Ser(77), Ser(80), and Ser(86)) were individually replaced with Asp residues to simulate phosphorylation. | Serine | protein kinase C alpha | Homo sapiens |
| 2 | MS/MS analysis verified that Ser(18) and Ser(80) were directly phosphorylated by PKCalpha in vitro. | Serine | protein kinase C alpha | Homo sapiens |
| 3 | MS/MS analysis verified that Ser(18) and Ser(80) were directly phosphorylated by PKCalpha in vitro. | Serine | protein kinase C alpha | Homo sapiens |
| 4 | These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility. | Serine | protein kinase C alpha | Homo sapiens |
| 5 | These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility. | Serine | protein kinase C alpha | Homo sapiens |