Title : Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2.

Pub. Date : 2014 Sep 1

PMID : 25082515






2 Functional Relationships(s)
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1 Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2. benzimidazole MET proto-oncogene, receptor tyrosine kinase Homo sapiens
2 Among these compounds bearing quinazoline and benzimidazole fragments, compound 7j exhibited the most potent inhibitory activity against c-Met and VEGFR-2 with IC50 of 0.05muM and 0.02muM, respectively. benzimidazole MET proto-oncogene, receptor tyrosine kinase Homo sapiens