Title : Intraganglionic signaling as a novel nasal-meningeal pathway for TRPA1-dependent trigeminovascular activation by inhaled environmental irritants.

Pub. Date : 2014

PMID : 25077949






4 Functional Relationships(s)
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1 We demonstrate here that resiniferatoxin ablation of TRPV1 expressing neurons significantly reduces meningeal blood flow responses to nasal administration of both TRPV1 and TRPA1 agonists. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 We demonstrate here that resiniferatoxin ablation of TRPV1 expressing neurons significantly reduces meningeal blood flow responses to nasal administration of both TRPV1 and TRPA1 agonists. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Homo sapiens
3 Accordingly resiniferatoxin also significantly reduces TRPV1 and CGRP immunostaining and TRPV1 and TRPA1 message levels in trigeminal ganglia. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Homo sapiens
4 Accordingly resiniferatoxin also significantly reduces TRPV1 and CGRP immunostaining and TRPV1 and TRPA1 message levels in trigeminal ganglia. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Homo sapiens