Title : Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.

Pub. Date : 2014 Mar 1

PMID : 25075329






2 Functional Relationships(s)
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1 The decreased catalytic activity (~20-fold lower with respect to the wild type) of a variant of CA II in which His64 is replaced with Ala (H64A CA II) can be enhanced by exogenous proton donors/acceptors, usually derivatives of imidazoles and pyridines, to almost the wild-type level. Pyridines carbonic anhydrase 2 Homo sapiens
2 The decreased catalytic activity (~20-fold lower with respect to the wild type) of a variant of CA II in which His64 is replaced with Ala (H64A CA II) can be enhanced by exogenous proton donors/acceptors, usually derivatives of imidazoles and pyridines, to almost the wild-type level. Pyridines carbonic anhydrase 2 Homo sapiens