Title : Poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells.

Pub. Date : 2014 Nov

PMID : 25072752






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The combination reduced Rad51 nuclear foci in Hep3B cells (not Huh7 cells), and silencing of Rad51 enhanced sensitivity of Huh7 cells to the DHMEQ-Olaparib combination. dhmeq-olaparib RAD51 recombinase Homo sapiens
2 Knockdown of AKT in Hep3B cells restored the number of Rad51 nuclear foci after DHMEQ-Olaparib treatment. dhmeq-olaparib RAD51 recombinase Homo sapiens