Title : Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate.

Pub. Date : 2014 Oct

PMID : 25062567






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Intriguingly, EGCG successfully reversed ROS, autophagy and acetylated FoxO1 in high-glucose treated H9c2 cells. epigallocatechin gallate forkhead box O1 Rattus norvegicus
2 CONCLUSION: Our findings suggest that FoxO1, especially the acetylated form, regulates high-glucose induced autophagy in H9c2 cardiomyoblasts, which can be prevented by EGCG via a possible ROS-FoxO1 pathway. epigallocatechin gallate forkhead box O1 Rattus norvegicus
3 CONCLUSION: Our findings suggest that FoxO1, especially the acetylated form, regulates high-glucose induced autophagy in H9c2 cardiomyoblasts, which can be prevented by EGCG via a possible ROS-FoxO1 pathway. epigallocatechin gallate forkhead box O1 Rattus norvegicus