Title : Elevated intracranial dopamine impairs the glutamate‑nitric oxide‑cyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy.

Pub. Date : 2014 Sep

PMID : 25059564






2 Functional Relationships(s)
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1 Chronic exposure of cultured cerebral cortex PCAs to DA treatment induced a dose-dependent decrease in the concentration of intracellular calcium, nitrites and nitrates, the formation of cGMP and the expression of NMDAR1, CaM, nNOS and sGC/cGMP. Dopamine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
2 High doses of DA (50 microM) significantly reduced NMDA-induced augmentation of the formation of cGMP and the contents of NMDAR1, CaM, nNOS, sGC and cGMP (P<0.01). Dopamine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus