Title : Autocrine positive regulatory feedback of glucocorticoid secretion: glucocorticoid receptor directly impacts H295R human adrenocortical cell function.

Pub. Date : 2014 Sep

PMID : 25058354






1 Functional Relationships(s)
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1 Interestingly, RU486 resulted in a significant CYP21A2 enzymatic blockade as demonstrated by a massive increase in 17-hydroxyprogesterone concentrations in RU486-treated H295R cell supernatants, while cortisol and 11-deoxycortisol secretions were reduced by more than 60%. 17-alpha-Hydroxyprogesterone cytochrome P450 family 21 subfamily A member 2 Homo sapiens