Title : Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.

Pub. Date : 2014 Sep 5

PMID : 25056956






2 Functional Relationships(s)
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Protein Name
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1 Nox2 activation requires two switches to be turned on simultaneously: a conformational change of the cytosolic protein p47(phox) and GDP/GTP exchange on the small GTPase Rac. Guanosine Diphosphate AKT serine/threonine kinase 1 Homo sapiens
2 Here we show that AA elicits GDP-to-GTP exchange on Rac at the cellular level, consistent with its role as a potent Nox2 activator. Guanosine Diphosphate AKT serine/threonine kinase 1 Homo sapiens