Title : Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

Pub. Date : 2014 Sep 1

PMID : 25049354






2 Functional Relationships(s)
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1 Subsequent experiments showed that MMP-8 exhibits TNF-alpha-converting enzyme (TACE) activity by cleaving the prodomain of TNF-alpha (A(74)/Q(75), A(76)/V(77) residues) and, furthermore, that M8I inhibits TACE activity more efficiently than TAPI-0, a general TACE inhibitor. m8i a disintegrin and metallopeptidase domain 17 Mus musculus
2 Subsequent experiments showed that MMP-8 exhibits TNF-alpha-converting enzyme (TACE) activity by cleaving the prodomain of TNF-alpha (A(74)/Q(75), A(76)/V(77) residues) and, furthermore, that M8I inhibits TACE activity more efficiently than TAPI-0, a general TACE inhibitor. m8i a disintegrin and metallopeptidase domain 17 Mus musculus