Title : Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

Pub. Date : 2014 Sep 15

PMID : 25047938






1 Functional Relationships(s)
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1 We have found that four taxanes with chemical modifications at positions C10 and C13 were active against all types of taxane resistant cell lines, resistant by P-gp overexpression, by mutations in the beta-tubulin binding site or by overexpression of the highly dynamic betaIII-tubulin isotype. taxane homeobox C10 Homo sapiens