Title : Docosahexaenoic acid reduces linoleic acid induced monocyte chemoattractant protein-1 expression via PPARγ and nuclear factor-κB pathway in retinal pigment epithelial cells.

Pub. Date : 2014 Oct

PMID : 25044948






5 Functional Relationships(s)
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Protein Name
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1 Docosahexaenoic acid reduces linoleic acid induced monocyte chemoattractant protein-1 expression via PPARgamma and nuclear factor-kappaB pathway in retinal pigment epithelial cells. Docosahexaenoic Acids C-C motif chemokine ligand 2 Homo sapiens
2 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Docosahexaenoic Acids C-C motif chemokine ligand 2 Homo sapiens
3 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Docosahexaenoic Acids C-C motif chemokine ligand 2 Homo sapiens
4 DHA at 50 and 100 muM effectively inhibited LA-induced MCP-1 expression and production (p < 0.05) and NF-kappaB activation. Docosahexaenoic Acids C-C motif chemokine ligand 2 Homo sapiens
5 CONCLUSION: DHA reduced LA-induced MCP-1 expression via a PPARgamma- and NF-kappaB-dependent pathway in ARPE-19 cells. Docosahexaenoic Acids C-C motif chemokine ligand 2 Homo sapiens