Title : Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway.

Pub. Date : 2014 Sep

PMID : 25043756






3 Functional Relationships(s)
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1 Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway. Dihydrotestosterone nuclear receptor subfamily 3 group C member 1 Homo sapiens
2 On immunofluorescence, activation of STAT5 and GR translocating into the nucleus after DHT treatment was confirmed. Dihydrotestosterone nuclear receptor subfamily 3 group C member 1 Homo sapiens
3 Activation was induced regardless of presence of AR and in cells devoid of AR, DHT used GR which formed direct complex with p-STAT5. Dihydrotestosterone nuclear receptor subfamily 3 group C member 1 Homo sapiens