Title : Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition.

Pub. Date : 2014 Aug 15

PMID : 25037914






3 Functional Relationships(s)
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1 Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARalpha/gamma activation and dual 5-LO/mPGES-1 inhibition. 2-aminothiazole prostaglandin E synthase Mus musculus
2 We have recently identified aminothiazole-featured pirinixic acids as dual 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors. 2-aminothiazole prostaglandin E synthase Mus musculus
3 Here we present the structure-activity relationship of these aminothiazole-featured pirinixic acids as dual PPARalpha/gamma agonists and discuss their advantages with their potential as dual 5-LO/mPGES-1 inhibitors in inflammatory and cancer diseases. 2-aminothiazole prostaglandin E synthase Mus musculus