Title : Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle.

Pub. Date : 2014 Oct 5

PMID : 25036266






1 Functional Relationships(s)
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1 Chloroquine, denatonium, dextromethorphan, noscapine and quinine, agonists for TAS2R3, TAS2R4, TAS2R10 and TAS2R14, induced strong endothelium-independent relaxations (responses between 82-96% of maximal relaxations) in phenylephrine pre-contracted guinea-pig aorta that persisted in the presence of L-type Ca2+ and KCa1.1-channel blockers. Quinine taste 2 receptor member 14 Homo sapiens