Title : Functional and biochemical interaction between PPARĪ± receptors and TRPV1 channels: Potential role in PPARĪ± agonists-mediated analgesia.

Pub. Date : 2014 Sep

PMID : 25014183






5 Functional Relationships(s)
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1 The role of PPARalpha in these pharmacological responses was confirmed by the ability of the PPARalpha antagonist GW6471 (10 muM) to block CLO-, WY14643- and GW7647-induced TRPV1 activation, and by the observation that modulation of PPARalpha levels via siRNA-mediated suppression or PPARalpha over-expression affected TRPV1 channel activation by PPARalpha agonists accordingly. GW 6471 peroxisome proliferator-activated receptor alpha Cricetulus griseus
2 The role of PPARalpha in these pharmacological responses was confirmed by the ability of the PPARalpha antagonist GW6471 (10 muM) to block CLO-, WY14643- and GW7647-induced TRPV1 activation, and by the observation that modulation of PPARalpha levels via siRNA-mediated suppression or PPARalpha over-expression affected TRPV1 channel activation by PPARalpha agonists accordingly. GW 6471 peroxisome proliferator-activated receptor alpha Cricetulus griseus
3 The role of PPARalpha in these pharmacological responses was confirmed by the ability of the PPARalpha antagonist GW6471 (10 muM) to block CLO-, WY14643- and GW7647-induced TRPV1 activation, and by the observation that modulation of PPARalpha levels via siRNA-mediated suppression or PPARalpha over-expression affected TRPV1 channel activation by PPARalpha agonists accordingly. GW 6471 peroxisome proliferator-activated receptor alpha Cricetulus griseus
4 The role of PPARalpha in these pharmacological responses was confirmed by the ability of the PPARalpha antagonist GW6471 (10 muM) to block CLO-, WY14643- and GW7647-induced TRPV1 activation, and by the observation that modulation of PPARalpha levels via siRNA-mediated suppression or PPARalpha over-expression affected TRPV1 channel activation by PPARalpha agonists accordingly. GW 6471 peroxisome proliferator-activated receptor alpha Cricetulus griseus
5 The role of PPARalpha in these pharmacological responses was confirmed by the ability of the PPARalpha antagonist GW6471 (10 muM) to block CLO-, WY14643- and GW7647-induced TRPV1 activation, and by the observation that modulation of PPARalpha levels via siRNA-mediated suppression or PPARalpha over-expression affected TRPV1 channel activation by PPARalpha agonists accordingly. GW 6471 peroxisome proliferator-activated receptor alpha Cricetulus griseus