Title : Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures.

Pub. Date : 2014 Jul

PMID : 25013176






1 Functional Relationships(s)
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1 Here we report that transfected 20-mer phosphorothioate-modified (PS) antisense oligonucleotides (ASOs) can recruit paraspeckle proteins to form morphologically normal and apparently functional paraspeckle-like structures containing no NEAT1 RNA. Oligonucleotides, Antisense nuclear paraspeckle assembly transcript 1 (non-protein coding) Mus musculus