Title : Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension.

Pub. Date : 2013 Dec

PMID : 25006397






1 Functional Relationships(s)
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1 In control human lung endothelial cell cultures, tumor necrosis factor alpha-induced nitric oxide (NO) production and S-nitrosation (SNO) of Cav-1 Cys-156 were associated with Src displacement and activation, Cav-1 Tyr-14 phosphorylation, and destabilization of Cav-1 oligomers within 5 minutes that could be blocked by eNOS or Src inhibition. Tyrosine tumor necrosis factor Homo sapiens