Title : Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.

Pub. Date : 2014

PMID : 25000190






1 Functional Relationships(s)
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1 The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-kappaB proteins, and abrogated the binding of NF-kappaB on COX-2 promoter. Melatonin collagen type XI alpha 2 chain Homo sapiens