Title : Depletion of globosides and isoglobosides fully reverts the morphologic phenotype of Fabry disease.

Pub. Date : 2014 Oct

PMID : 24992926






1 Functional Relationships(s)
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1 Owing to the fact that alphaGalA-deficient humans and mice accumulate the same glycosphingolipids (i.e. globosides, galabiosylceramide and isoglobosides), alphaGalA-deficient mice were crossed with mice deficient in enzymes synthesizing these classes of glycosphingolipids (i.e. globotrihexosylceramide and isoglobotrihexosylceramide synthase, respectively). Globosides galactosidase, alpha Mus musculus