Title : Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).

Pub. Date : 2014 Aug 15

PMID : 24990952






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids membrane bound O-acyltransferase domain containing 2 Homo sapiens
2 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT). Phosphatidic Acids membrane bound O-acyltransferase domain containing 2 Homo sapiens
3 Although PLD has been widely implicated in the generation of PA needed for mTOR activation, it is becoming clear that PA generated via the LPAAT and DGK pathways is also involved in the regulation of mTOR. Phosphatidic Acids membrane bound O-acyltransferase domain containing 2 Homo sapiens