Title : Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.

Pub. Date : 2014 Aug 22

PMID : 24986863






1 Functional Relationships(s)
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1 By altering IDH1, these mutations target a critical step in reductive glutamine metabolism, the metabolic pathway that converts glutamine ultimately to acetyl-CoA for biosynthetic processes. Acetyl Coenzyme A isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens