Pub. Date : 2014 Nov
PMID : 24977346
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Incubation with DETA NONOate (a stable NO donor) and 8-Br-cGMP (a cell membrane permeable analog of cGMP) attenuated Akt phosphorylation at Ser-473, which was prevented by Rp-8-Br-PET-cGMPS (a specific inhibitor of PKG) and calyculin A (an inhibitor of protein phosphatase 1 and 2A) but not by okadaic acid (a selective inhibitor of protein phosphatase 2A). | 2,2'-(hydroxynitrosohydrazono)bis-ethanamine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Inhibition of Akt enhanced the relaxation and cGMP elevation of porcine pulmonary arteries induced by DETA NONOate or sodium nitroprusside, which was prevented by zaprinast, a specific inhibitor of PDE5. | 2,2'-(hydroxynitrosohydrazono)bis-ethanamine | AKT serine/threonine kinase 1 | Homo sapiens |