Pub. Date : 1989 May
PMID : 2497649
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCK did not cause residual enzyme secretion but caused desensitization that was rapid, temperature dependent, dependent on extracellular calcium, reversible with time, and prevented but not reversed by CCK receptor antagonists. | Calcium | cholecystokinin | Homo sapiens |
| 2 | CCK-8 caused heterologous desensitization of pepsinogen secretion stimulated by agonists that interact with receptors to cause mobilization of cellular calcium and activation of protein kinase C or by agonists that bypass receptors to activate these mediators directly; however, CCK-8 did not induce desensitization of the stimulation caused by any secretagogue whose actions are mediated by adenosine 3",5"-cyclic monophosphate. | Calcium | cholecystokinin | Homo sapiens |