Title : Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer.

Pub. Date : 2014 Sep 1

PMID : 24973425






1 Functional Relationships(s)
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1 Activation of these bypass RTKs attenuated lapatinib-induced apoptosis and suppression of cell motility, mechanistically because of restimulating the shared downstream AKT or ERK signaling, as well as restimulating WNT signaling and epithelial-to-mesenchymal transition (EMT)-like process. Lapatinib AKT serine/threonine kinase 1 Homo sapiens