Pub. Date : 2014 Sep
PMID : 24969051
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present study was to investigate the number and function of CD8+HLA-DR+ cells, which are considered to be activated cytotoxic T lymphocytes (CTLs), in peripheral blood to further examine the pathogenesis of severe aplastic anemia (SAA). | saa | CD8a molecule | Homo sapiens |
| 2 | The proportion of CD8+HLA-DR+ T cells was analyzed by flow cytometry in peripheral blood and was identified to be significantly higher in untreated SAA than in remission patients and in the controls. | saa | CD8a molecule | Homo sapiens |
| 3 | The expression of perforin, granzyme B, TNF-beta and FasL in CD8+HLA-DR+ T cells was analyzed by flow cytometry and PCR, which revealed increased expression in the untreated SAA group compared with that in the control group. | saa | CD8a molecule | Homo sapiens |
| 4 | Furthermore, the apoptosis of CD3- bone marrow cells from normal individuals was enhanced following co-culture with CD8+HLA-DR+ T cells from untreated SAA patients. | saa | CD8a molecule | Homo sapiens |
| 5 | In conclusion, the present study demonstrated that CD8+HLA-DR+ T cells may contribute to bone marrow failure in SAA. | saa | CD8a molecule | Homo sapiens |