Title : Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.

Pub. Date : 2014 Aug 15

PMID : 24966089






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Amiloride, an epithelial Na(+) channel (ENaC) inhibitor, normalized the BP of KO mice fed HK diets, suggesting that lack of Cyp2c44 in the CD enhances ENaC activity and increases Na(+) absorption in KO mice fed HK diets. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus
2 Amiloride, an epithelial Na(+) channel (ENaC) inhibitor, normalized the BP of KO mice fed HK diets, suggesting that lack of Cyp2c44 in the CD enhances ENaC activity and increases Na(+) absorption in KO mice fed HK diets. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus